Dec 2011 Update

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Category: Clayton's Blog

It's been a busy year.  Hoping to take the summer off to advance my Neuroscience research, I was instead waylaid by a number of interesting business opportunities.  Several of them are in process (and exciting), but they were something of a distraction from this site and the associated work.

Fortunately, part of that process involved purchasing and setting up several domain names.  While I was at it, I snagged "eviduction" and "eviduce", the synthesis of evidence and deduction.  I'm ecstatic that I found a phrase that was both appropriate and accessible.  Naturally, I now have a site to occupy this space (though the template needs some work).

Along with my ongoing business activities (to pay the bills), the new challenge is to balance the research itself and progress on the platform.  Except for some initial setup on this site, the research will (logically) win. 

While I have (well) over a thousand pages of neuroscience notes, it has been difficult to get any broad "reviewable" subject to a satisfactory level of completeness.  Instead, I have isolated a simple argument from my ER Exit research that should be short enough and complete enough to test the waters.  I'm optimistic that this can be completed during my holiday vacation and submitted somewhere.  I anticipate considerable frustration getting a pure theory (even review) paper published and can only hope to be pleasantly surprised.

In an ironically cyclical argument (either "for posterity" or no one cares to read it anyway), here's the current tallies of my various documents:

  • Receptor Number and Synaptic Plasticity (890 pages).  This is a review of the mechanisms of plasticity, with an emphasis on AMPARs.  My goal is to understand and highlight the key signaling pathways for use in higher-level arguments.
  • Neuroscience Foundations of a Cortical Algorithm (228 pages).  This is one that I'm working towards.  It's a single algorithm for cortical function and the role that other systems (dopamine and serotonin especially) have within that framework.
  • Cognition (68 pages).  This is the beginning of a more accessible cognition paper that builds on the neuroscience foundations.  It explains how complex concepts like "objects" can be derived from the single neurological algorithm.  Unfortunately, a lot of this document includes citations for papers that I was not able to find (all pre-Mendeley).
  • Neuro Notes (95 pages).  As I find that certain content isn't relevant to the main flow of an argument, the content (quotes and writings) are relegated to this document.  I do sometimes come back to find and retrieve content when it later becomes relevant.

That's 1281 pages of quotes and content and I still haven't published anything.  Even I realize that's a little crazy except that I see the risk of publishing my best work without reputation or solid neuroscience underpinnings.

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